<p style="text-indent: 2em; text-align: left;">In order to better guide clinical safe and rational drug use, our company, in accordance with the requirements of the announcement (No. 20 of 2023) issued by the National Medical Products Administration regarding the "Special Provisions for Drug Registration Management of Traditional Chinese Medicine", has actively carried out a market research on the safety information items of Fu'an Granules. We have revised the contents of the instructions and labels [adverse reactions], [precautions], and [cautions] and completed the supplementary application. To ensure that patients fully understand the revised information in the instructions, and to facilitate their use, we will inform them of the changes in the form of a notification letter on our company's official website. </p><p style="text-indent: 2em; text-align: left;">I. The changes in the instruction manual are as follows: </p><p style="text-indent: 2em; text-align: left;">(1). 【Adverse Reactions】 It has been changed to "The ingredients contained in this product may cause adverse reactions such as rash, itching, and allergic reactions." </p><p style="text-indent: 2em; text-align: left;">(2). 【Precautions】 Have been changed to "1. Pregnant women are prohibited from using. 2. Those who are allergic to this product or its components are also prohibited from using." </p><p style="text-indent: 2em; text-align: left;">(III). [Notes] The indication has been changed to "1. Caution for those with impaired liver or kidney function." </p><p style="text-indent: 2em; text-align: left;">2. Caution is advised for patients with diabetes. </p><p style="text-indent: 2em; text-align: left;">3. Elderly or weak individuals should use with caution. </p><p style="text-indent: 2em; text-align: left;">4. This product should not be used in excessive amounts or for an extended period. </p><p style="text-indent: 2em; text-align: left;">"Use of this product is prohibited if its properties change." </p><p style="text-indent: 2em; text-align: left;">II. The revised content of the manual is applicable to our company's Abian Granules in the market circulation and will not affect the normal use of the medicine. </p><p style="text-indent: 2em; text-align: left;">III. If the medicine purchased by the patient is the original unmodified one, the updated instructions can be obtained from the pharmacy or hospital where the purchase was made. If for any reason it is impossible to obtain the updated instructions, please contact our company according to the following phone number. Our company can provide the updated paper version of the instructions. If you have any other questions, please feel free to call us. (Contact number: 0592-7266588) </p><p style="text-indent: 2em; text-align: left;">This is to inform you! </p><p style="text-indent: 2em; text-align: left;">Xiamen Traditional Chinese Medicine Factory Co., Ltd. </p><p style="text-indent: 2em; text-align: left;">December 19th, 2025</p>